Silica-Anchored Proline-Copper(I) as an Efficient and Recyclable Catalyst for the Sonogashira Reaction

Abstract

A novel silica-anchored proline-copper(I) organic-inorganic hybrid material as an efficient catalyst for the Sonoga­shira reaction was developed. Terminal alkynes were reacted with aryl iodides and bromides smoothly in the presence of a proline-functionalized silica-anchored copper(I) catalyst in DMF to afford the corresponding cross-coupling products in good to excellent yields. Furthermore, silica-anchored proline-copper(I) catalyst was recovered and recycled by a simple filtration of the reaction solution and reused for six times without significant decreases in activity.

Key words

Sonogashira coupling reaction - organic-inorganic hybrid material - silica-anchored proline-copper(I) catalyst - heterogeneous catalysis - terminal alkynes - aryl iodides - aryl bromides

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