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Eur J Pediatr Surg 2012; 22(05): 374-383
DOI: 10.1055/s-0032-1329531
Review
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Management of Pulmonary Hypertension in Neonates with Congenital Diaphragmatic Hernia

S. Vijfhuize
1   Departments of Pediatric Surgery, Neonatology, and Intensive Care, Sophia Children's Hospital, Erasmus MC, Rotterdam, The Netherlands
,
T. Schaible
2   Department of Intensive Care, Kinderklinikum Mannheim, Mannheim, Germany
,
U. Kraemer
1   Departments of Pediatric Surgery, Neonatology, and Intensive Care, Sophia Children's Hospital, Erasmus MC, Rotterdam, The Netherlands
,
T. E. Cohen-Overbeek
3   Division of Prenatal Medicine, Department of Obstetrics and Gynaecology, Sophia Children's Hospital, Erasmus MC, Rotterdam, The Netherlands
,
D. Tibboel
1   Departments of Pediatric Surgery, Neonatology, and Intensive Care, Sophia Children's Hospital, Erasmus MC, Rotterdam, The Netherlands
,
I. Reiss
1   Departments of Pediatric Surgery, Neonatology, and Intensive Care, Sophia Children's Hospital, Erasmus MC, Rotterdam, The Netherlands
› Author Affiliations
Further Information

Publication History

10 September 2012

17 September 2012

Publication Date:
31 October 2012 (online)

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Abstract

Pulmonary hypertension associated with congenital diaphragmatic hernia is still one of the major challenges in neonatal intensive care units. Several relevant pathways in its pathogenesis have been described and studied, but the absence of well-designed randomized controlled trials and the scattered data on the pharmacokinetics and pharmacodynamics of most of the drugs used in these patients hamper progress significantly. This review aims to give an overview of current management strategies in the antenatal and neonatal phase, and provides founded clinical recommendations.

Keywords

congenital diaphragmatic hernia - pulmonary hypertension - neonates - NO pathway
 

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