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Synlett 2016; 27(10): 1450-1455
DOI: 10.1055/s-0035-1561416
DOI: 10.1055/s-0035-1561416
synpacts
A Massé Shot: Transition-Metal-Catalyzed Selective meta-C–H Functionalization (ortho-Metallation and para-Bromination Relay)
Further Information
Publication History
Received: 31 December 2015
Accepted after revision: 22 February 2016
Publication Date:
17 March 2016 (online)
Abstract
Reviewed herein are a number of modern approaches for the meta-selective direct C–H functionalization of substituted arenes, including a recent discovery on Ru-catalyzed meta-bromination is also discussed with the mechanistically interesting features (ortho-metallation and para-functionalization relay).
1 Introduction
2 Transition-Metal-Mediated meta-C–H Activation
3 Ruthenium-Catalyzed meta-C–H Bromination
4 Conclusion and Future Directions
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