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Synlett 2017; 28(01): 19-23
DOI: 10.1055/s-0036-1588643
DOI: 10.1055/s-0036-1588643
synpacts
Toward Sustainable Trifluoromethylation Reactions: Sodium Triflinate under the Spotlight
Further Information
Publication History
Received: 23 September 2016
Accepted after revision: 12 October 2016
Publication Date:
07 November 2016 (online)
Dedicated to Dr. Bernard Langlois
Abstract
Direct trifluoromethylation of organic molecules is of upmost importance in medicinal chemistry and agrochemical research. However, finding sustainable reaction conditions should be a priority for chemists to improve the applicability of their research. Herein, we highlight recent advances in transition-metal-free and photochemical activation of sodium triflinate, a commercially available and easy-to-handle source of CF3 radical.
1. Introduction
2. Transition-Metal-Free Activation of Sodium Triflinate
3. Photochemical Activation of Sodium Triflinate
4. Conclusions and Outlook
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For a pioneering example, see:
For a hydrotrifluoromethylation reaction with Umemoto reagent, see: