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CC BY-ND-NC 4.0 · SynOpen 2018; 02(02): 0096-0104
DOI: 10.1055/s-0037-1609449
DOI: 10.1055/s-0037-1609449
review
Methods for Arylethylation of Amines and Heteroarenes
Further Information
Publication History
Received: 21 February 2018
Accepted: 18 March 2018
Publication Date:
03 April 2018 (online)
Dedicated to my friend Norbert Breitschaft, who died on 7th of February, 2018.
Abstract
Compared with standard N-methylation, benzylation, and alkylation of amines and N-heterocycles, N-arylethylation is significantly more challenging. In this Review the available methods for N-arylethylation are summarized, with a special focus on efficiency, selectivity, availability of the required building blocks, and ecological aspects.
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