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Synlett 2019; 30(12): 1431-1436
DOI: 10.1055/s-0037-1611857
DOI: 10.1055/s-0037-1611857
letter
1,4-Diazabicyclo[2.2.2]octane-Catalyzed Multicomponent Domino Strategy for the Synthesis of Tetrasubstituted NH-Pyrroles
We are grateful for the National Natural Science Foundation of China (No. 21676253 and No. 21776254) for financial support.Further Information
Publication History
Received: 25 April 2019
Accepted after revision: 20 May 2019
Publication Date:
07 June 2019 (online)
Abstract
A mild and efficient 1,4-diazabicyclo[2.2.2]octane (DABCO)-catalyzed three-component domino reaction was developed for the synthesis of highly functionalized NH-pyrroles from arylglyoxal monohydrates, enamino esters, and cyclic 1,3-dicarbonyl compounds in 1,4-dioxane at room temperature for 0.5 hours. Various substituted NH-pyrroles were obtained in moderate to good yields.
Key words
multicomponent reaction - pyrroles - DABCO - cyclization - arylglyoxal monohydrates - enamino estersSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0037-1611857.
- Supporting Information