It was the aim of the study to analyse the haemostatic system during
a high standardized intensive short-term (30 s) exercise (anaerobic
Wingate test). Blood samples were taken from 15 male subjects before
(t0), and within 2 (t1), 9 (t2) and 30 min
(t3) after the test. We found that the partial thromboplastin time
was markedly shortened, whereas the prothrombin time increased slightly from
t0 to t1 (p < 0.002) and remained
elevated (t3, p < 0.046). Factor VIII increased
from t0 to t1 (p < 0.001) and remained
elevated as well (t3, p < 0.001). Fibrin monomers
were approximately 15 times higher immediately post-exercise (t1,
p < 0.001) and continued to be elevated (t3,
p < 0.004). The tissue plasminogen activator increased by 4
times after exercise (t1, p < 0.001) and remained
elevated (t3, p < 0.002). The d-dimers increased
from t0 to t1 (p < 0.001) as well and
remained elevated (t3, p < 0.005). Thrombopoietin
concentrations were unchanged, whereas the vascular endothelial growth factor
increased immediately post-exercise (t0 to t1,
p < 0.011 resp. at t2 p < 0.019)
and returned to the control level at t3
(p < 0.878). In conclusion, it was found that prothrombotic
markers and, even more pronounced, those of the fibrinolytic system were
increased. The study provides evidence that due to intensive short-term
exercise the balance of the haemostatic system is shifted to a higher
equilibrium. Theoretically, the data show that in the case of a subject with
risk factors such as impaired fibrinolysis, unfavourable conditions cannot be
excluded.
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