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Synthesis 2005(10): 1569-1571
DOI: 10.1055/s-2005-865360
DOI: 10.1055/s-2005-865360
SHORTPAPER
© Georg Thieme Verlag Stuttgart · New York
Synthesis of 2,4,5-Trisubstituted Oxazoles
Further Information
Received
18 October 2004
Publication Date:
02 May 2005 (online)
Publication History
Publication Date:
02 May 2005 (online)
Abstract
2,4,5-Trisubstituted oxazoles were synthesized in good yields starting from α-methylene ketones by nitrosation, condensation with aldehydes and reduction with zinc in acetic acid at 40 °C. (5-Methyl-2-phenyloxazol-4-yl)ethanol was prepared by reduction of ethyl (5-methyl-2-phenyloxazol-4-yl)acetate with LiAlH4.
Key words
oxazole - 2,4,5-trisubstituted oxazole - (5-methyl-2-phenyloxazol-4-yl)ethanol - α-diketone monooxime - condensation
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