A Multicomponent Domino Reaction and in situ Aerobic Oxidation Sequence for the First One-Pot Synthesis of Polycyclic Benzimidazoles from 1,3-Dicarbonyl Derivatives

Abstract

A facile one-pot synthesis of functionalized pyrido[1,2-a]benzimidazoles is described via a molecular-sieves-promoted three-component domino reaction and in situ aerobic oxidation sequence from 1,3-dicarbonyls, aromatic o-diamines and unsaturated aldehydes. This environmentally friendly sequence does not require any harmful reagents, and liberates water as the only by-product. The desired products are obtained in good to excellent yields and generally with high purity, after simple filtration.

Key words

multicomponent reaction - 1,3-dicarbonyls - benzimidazoles - heterogeneous catalysis - aerobic oxidation

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