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CC BY-NC-ND 4.0 · Geburtshilfe Frauenheilkd 2019; 79(04): 358-365
DOI: 10.1055/a-0774-7924
GebFra Science
Review/Übersicht
Georg Thieme Verlag KG Stuttgart · New York

Tuberculosis in Pregnancy – a Summary

Article in several languages: English | deutsch
Benjamin Wolf   *
1   Abteilung für Geburtsmedizin, Universitätsfrauenklinik Leipzig, Universitätsklinikum Leipzig AöR, Leipzig, Germany
,
Marco Krasselt   *
2   Sektion Rheumatologie, Klinik für Gastroenterologie und Rheumatologie, Universitätsklinikum Leipzig AöR, Leipzig, Germany
,
Jonathan de Fallois
3   Interdisziplinäre Internistische Intensiveinheit, Universitätsklinikum Leipzig AöR, Leipzig, Germany
,
Amrei von Braun   **
4   Fachbereich Infektions- und Tropenmedizin, Klinik für Gastroenterologie und Rheumatologie, Universitätsklinikum Leipzig AöR, Leipzig, Germany
,
Holger Stepan   **
1   Abteilung für Geburtsmedizin, Universitätsfrauenklinik Leipzig, Universitätsklinikum Leipzig AöR, Leipzig, Germany
› Author Affiliations
Further Information

Publication History

received 26 July 2018
revised 23 October 2018

accepted 23 October 2018

Publication Date:
08 January 2019 (online)

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Abstract

In recent years, the incidence of tuberculosis in pregnancy in the industrialised countries has increased. Tuberculosis in pregnancy is associated with an increased risk for the mother and child. Even if no figures are available for Germany, an increase in the number of tuberculosis cases among pregnant women can be assumed due to the migratory flows; current data from the USA, for example, also show an increasing incidence of tuberculosis in pregnant women in recent years. The physiological and immunological changes that occur during pregnancy are likely to have a negative impact on the course of the disease and may make it more difficult to confirm the diagnosis. There are no internationally standardised recommendations for diagnosing latent tuberculosis infections. When screening for TB is performed in specific risk populations, an Interferon-γ Release Assay (IGRA) should preferably be carried out according to the current study data. If corresponding symptoms are present and an IGRA test is positive, further diagnostics are indicated, also in pregnancy. If tuberculosis is confirmed, the fact that a woman is pregnant must not delay the initiation of anti-tuberculosis therapy, as an early start of therapy is associated with a more favourable outcome for both mother and child. The common first-line therapeutic drugs may also be used during pregnancy and are considered safe. The treatment of latent tuberculosis during pregnancy is disputed.

Key words

infections - pregnancy - tuberculosis - immunological changes - epidemiology - therapy

* BW and MK contributed in equal shares.


** AvB and HS contributed in equal shares.


 

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