Abstract
Background and study aims Endocuff Vision improves adenoma detection rates in patients without inflammatory
bowel disease. This study aimed to investigate the safety and feasibility of Endocuff
Vision-assisted high-definition white light endoscopy (HDWLE) with dye-spray chromoendoscopy
for detection of dysplasia in patients with ulcerative colitis.
Patients and methods Patients with clinically inactive ulcerative colitis due for dysplasia surveillance
were recruited. Procedural endpoints included safety, cecal intubation rate (CIR),
terminal ileum intubation rate (TIR), withdrawal time, polyp detection rate, dysplasia
detection rate (DDR), and sessile serrated lesion detection rate.
Results Twenty-five patients (9 female, median age 57 [range 28 – 82] years) were studied.
Endocuff Vision-assisted HDWLE was completed in all participants, with a CIR of 100 %,
in a median 4 minutes (range 2 – 16), and a TIR of 88% in a median of 6.5 minutes
(range 3 – 19). Median withdrawal time was 18 minutes (range 10 – 55), including application
of dye-spray, biopsies and polypectomy. The Mayo Endoscopic subscore was 0 in 11,
1 in 9, and 2 in 5 patients. The DDR was 24 % (6 patients had a total of 12 dysplastic
lesions) and sessile serrated lesion detection rate was 12 % (3 patients had a total
of 4 sessile serrated polyps). No serious adverse events occurred, with one patient
developing clinically insignificant minor mucosal bleeding.
Conclusion Endocuff Vision-assisted HDWLE is feasible and safe in patients with ulcerative colitis
undergoing dysplasia surveillance. Further studies are required to assess superiority
of this technique compared with standard high-definition white light endoscopy with
chromoendoscopy.
