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Diabetologie und Stoffwechsel 2021; 16(03): 225-231
DOI: 10.1055/a-1398-8387
Kasuistik

Unklare Lymphadenopathie mit Panzytopenie bei einer Patientin mit rezidivierenden Hypoglykämien

Nonspecific lymphadenopathy with pancytopenia in a patient with recurrent hypoglycaemia
Anna M. Lindmeyer
1   St. Josef-Hospital, Diabeteszentrum Bochum/Hattingen, Ruhr-Universität Bochum, Germany
,
Michael A. Nauck
1   St. Josef-Hospital, Diabeteszentrum Bochum/Hattingen, Ruhr-Universität Bochum, Germany
,
Juris J. Meier
1   St. Josef-Hospital, Diabeteszentrum Bochum/Hattingen, Ruhr-Universität Bochum, Germany
2   Augusta Kliniken Bochum, Klinik für Innere Medizin, Gastroenterologie und Diabetologie
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Zusammenfassung

Eine Patientin wurde aufgrund rezidivierender postprandialer Hypoglykämien nach Roux-en-Y-Magenbypass mit Diazoxid behandelt, nachdem eine Ernährungsumstellung keine Symptomlinderung erzielt hatte. Nach Eindosierung von Diazoxid mit guter Akutverträglichkeit wurde die Patientin entlassen. Eine Woche nach Therapieeinleitung kam es zu einer Lymphadenopathie und Panzytopenie. Es fanden sich keine Hinweise auf das Vorliegen eines Infekts. Nach Absetzen von Diazoxid sistierten die Beschwerden. Unser Fallbericht weist auf seltene unerwünschte hämatologische Arzneimittelwirkungen unter Diazoxid hin.

Abstract

A patient was admitted for the treatment of recurrent postprandial hypoglycaemia after Roux-en-Y gastric bypass. Diazoxide was initiated after dietary recommendations had failed to relieve symptoms. The patient was discharged after the drug was administered with good acute tolerance. One week after initiation of therapy she developed lymphadenopathy and pancytopenia. There was no clinical evidence of an infection. After discontinuing diazoxide, the symptoms subsided. Our case report describes rare haemotological adverse drug reactions under diazoxide.

Schlüsselwörter

Hypoglykämien - Diazoxid - Panzytopenie - Lymphadenopathie - bariatrische Chirurgie

Key words

hypoglycaemia - diazoxide - pancytopenia - lymphadenopathy - bariatric surgery


Publikationsverlauf

Eingereicht: 04. Januar 2021

Angenommen: 23. Februar 2021

Artikel online veröffentlicht:
13. Mai 2021

© 2021. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

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