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Synlett 2021; 32(14): 1379-1384
DOI: 10.1055/a-1479-8264
DOI: 10.1055/a-1479-8264
synpacts
Transition-Metal-Catalyzed Alkylation of Polyfluoroarenes through C–F Bond Cleavage
The authors thank the National Natural Science Foundation of China (grants nos. 21831002 and 21672033), the Fundamental Research Funds for the Central Universities, and the Ten Thousand Talents Program for their generous financial support.
Abstract
The polyfluoroarenes are a subgroup of organofluorines that are widely utilized in both medicinal chemistry and materials science. We briefly summarize recent advances in the synthesis of these important compounds, with particular attention to our recent CuH-catalyzed defluorinative alkylation of polyfluoroarenes with alkenes in a highly site-selective C–F bond-cleavage fashion.
1 Introduction
2 Transition-Metal-Catalyzed Alkylation through Selective C–F Bond Cleavage
3 CuH-Catalyzed Defluorinative Alkylation of Polyfluoroarenes with Alkenes
4 Summary and Outlook
Publikationsverlauf
Eingereicht: 05. April 2021
Angenommen: 12. April 2021
Accepted Manuscript online:
12. April 2021
Artikel online veröffentlicht:
28. April 2021
© 2021. Thieme. All rights reserved
Georg Thieme Verlag KG
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For Ni-catalyzed arylations, see:
For Pd-catalyzed arylations, see: