Synlett 2021; 32(14): 1379-1384
DOI: 10.1055/a-1479-8264
synpacts

Transition-Metal-Catalyzed Alkylation of Polyfluoroarenes through C–F Bond Cleavage

Qian Zhang
a   Jilin Province Key Laboratory of Organic Functional Molecular Design and Synthesis, Department of Chemistry, Northeast Normal University, Changchun 130024, P. R. of China
,
Tao Xiong
a   Jilin Province Key Laboratory of Organic Functional Molecular Design and Synthesis, Department of Chemistry, Northeast Normal University, Changchun 130024, P. R. of China
,
Qian Zhang
a   Jilin Province Key Laboratory of Organic Functional Molecular Design and Synthesis, Department of Chemistry, Northeast Normal University, Changchun 130024, P. R. of China
b   State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032, P. R. of China
› Institutsangaben
The authors thank the National Natural Science Foundation of China (grants nos. 21831002 and 21672033), the Fundamental Research Funds for the Central Universities, and the Ten Thousand Talents Program for their generous financial support.


Abstract

The polyfluoroarenes are a subgroup of organofluorines that are widely utilized in both medicinal chemistry and materials science. We briefly summarize recent advances in the synthesis of these important compounds, with particular attention to our recent CuH-catalyzed defluorinative alkylation of polyfluoroarenes with alkenes in a highly site-selective C–F bond-cleavage fashion.

1 Introduction

2 Transition-Metal-Catalyzed Alkylation through Selective C–F Bond Cleavage

3 CuH-Catalyzed Defluorinative Alkylation of Polyfluoroarenes with Alkenes

4 Summary and Outlook



Publikationsverlauf

Eingereicht: 05. April 2021

Angenommen: 12. April 2021

Accepted Manuscript online:
12. April 2021

Artikel online veröffentlicht:
28. April 2021

© 2021. Thieme. All rights reserved

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany