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CC BY-NC-ND 4.0 · Synlett 2022; 33(02): 109-115
DOI: 10.1055/a-1499-8679
DOI: 10.1055/a-1499-8679
synpacts
EuCheMS Organic Division Young Investigator Workshop
Photoredox-Enabled Decarboxylative Synthesis of Unnatural α-Amino Acids
Financial support from the Svenska Forskningsrådet Formas (2019-01269), the Vetenskapsrådet (Swedish Research Council, 2020-04764), the Magnus Bergvalls Stiftelse (Magnus Bergvall foundation), and the Kungliga Tekniska Högskolan (KTH Royal Institute of Technology) are gratefully acknowledged. The Olle Engkvist Foundation is kindly acknowledged for a postdoctoral fellowship to A. S.
Abstract
Recently, development of general synthetic routes to unnatural α-amino acids has gained significant momentum, driven by the high demand for such building blocks in fundamental research within molecular and structural biology, as well as for development of new pharmaceuticals. Herein, we highlight the recent progress in employing photoredox-mediated synthetic methods for accessing unnatural α-amino acids with a focus on various decarboxylative radical-based strategies.
Publication History
Received: 08 April 2021
Accepted after revision: 05 May 2021
Accepted Manuscript online:
05 May 2021
Article published online:
23 June 2021
© 2021. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)
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