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Thromb Haemost 2022; 122(07): 1076-1084
DOI: 10.1055/a-1690-8897
Review Article

Proteomics in Thrombosis and Hemostasis

Natasha Letunica
1   Department of Haematology, Murdoch Children's Research Institute, Melbourne, Australia
,
Suelyn Van Den Helm
1   Department of Haematology, Murdoch Children's Research Institute, Melbourne, Australia
,
Conor McCafferty
1   Department of Haematology, Murdoch Children's Research Institute, Melbourne, Australia
2   Department of Paediatrics, The University of Melbourne, Melbourne, Australia
,
Ella Swaney
1   Department of Haematology, Murdoch Children's Research Institute, Melbourne, Australia
2   Department of Paediatrics, The University of Melbourne, Melbourne, Australia
,
Tengyi Cai
1   Department of Haematology, Murdoch Children's Research Institute, Melbourne, Australia
2   Department of Paediatrics, The University of Melbourne, Melbourne, Australia
,
Chantal Attard
1   Department of Haematology, Murdoch Children's Research Institute, Melbourne, Australia
2   Department of Paediatrics, The University of Melbourne, Melbourne, Australia
,
Vasiliki Karlaftis
1   Department of Haematology, Murdoch Children's Research Institute, Melbourne, Australia
2   Department of Paediatrics, The University of Melbourne, Melbourne, Australia
,
Paul Monagle
1   Department of Haematology, Murdoch Children's Research Institute, Melbourne, Australia
2   Department of Paediatrics, The University of Melbourne, Melbourne, Australia
3   Department of Clinical Haematology, Royal Children's Hospital, Melbourne, Australia
4   Kids Cancer Centre, Sydney Children's Hospital, Randwick, Australia
,
Vera Ignjatovic
1   Department of Haematology, Murdoch Children's Research Institute, Melbourne, Australia
2   Department of Paediatrics, The University of Melbourne, Melbourne, Australia
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Abstract

Proteomics, the simultaneous study of all proteins in a given cell, tissue or organism, is an innovative approach used to identify novel markers for diagnosis, prognosis and the pathophysiological mechanisms associated with diseases. Proteomic methodologies have been used in a variety of contexts such as investigating changes in protein abundance that may occur with disease presence, the response to therapeutic treatments as well as the impacts of age on the plasma proteome.

Over the last decade, significant technological advancements in proteomic techniques have resulted in an increase in the use of proteomics in thrombosis and hemostasis research, particularly in order to identify relevant and novel clinical markers associated with bleeding and thrombosis. This mini-review explores the use of proteomics in the setting of thrombosis and hemostasis from 2010-2020, across five main domains (platelets, blood clot composition, stroke, venous thromboembolism, and therapeutics), as well as provides insights into key considerations for conducting proteomic studies.

Keywords

proteomics - thrombosis - hemostasis


Publication History

Received: 10 October 2021

Accepted: 03 November 2021

Accepted Manuscript online:
09 November 2021

Article published online:
29 December 2021

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