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DOI: 10.1055/a-1774-7077
Dihalooxygenation of Alkynes and Alkynols: Preparation of 2,2-Dihaloketones and gem-Dihalolactols
This research project was supported by the Thailand Research Fund (TRF; RSA6180045 for C.T.), the Thailand Science Research and Innovation (TSRI) for Chulabhorn Research Institute (Grant No. 313/2220) and for Chulabhorn Graduate Institute, Chulabhorn Royal Academy (FFB640035 Project Code 50171). This research was also supported in part by the grant from Center of Excellence on Environmental Health and Toxicology (EHT), OPS, Ministry of Higher Education, Science, Research and Innovation. NC was also grateful for the support from the Royal Golden Jubilee (RGJ) scholarship program (PHD/0139/2560).
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Abstract
A mild and convenient method for the synthesis of 2,2-dihaloketones and gem-dihalolactols has been developed. For the synthesis of 2,2-dihaloketones, alkynes were employed as substrates to react with halogenating agents, Cl2 or ClBr, that were generated in situ from aqueous HCl and NCS or NBS, respectively. On the other hand, gem-dihalolactols could be prepared from alkynol substrates by using the same reaction conditions. This method could be applied to a broad range of substrates to give the corresponding products in low to good yields.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/a-1774-7077.
- Supporting Information
Publikationsverlauf
Eingereicht: 23. Januar 2022
Angenommen nach Revision: 17. Februar 2022
Accepted Manuscript online:
17. Februar 2022
Artikel online veröffentlicht:
15. März 2022
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