The Conceptual Development of a Conjunctive Olefination

Abstract

We recently discovered a functional group tolerant and transition-metal-free conjunctive olefination reaction with applications in late-stage functionalization chemistry. In this Synpacts contribution, we analyze the conceptual background that has stimulated the discovery of this reactivity and reflect on the key aspects of its development.

1 Introduction

2 Conceptual Background

2.1 Photoredox-Mediated Giese Reaction

2.2 Photoredox Radical-Polar Reactivity

3 The Development of the Process

4 Conclusion

Key words

photoredox catalysis - Wittig reaction - radical-polar crossover - conjunctive olefination - radical chemistry

Publication History

Received: 24 February 2022

Accepted after revision: 03 March 2022

Accepted Manuscript online:
03 March 2022

Article published online:
01 April 2022

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