Synlett 2022; 33(20): 1961-1967
DOI: 10.1055/a-1890-8375
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Transition-Metal-Catalyzed Regioselective C–H Borylation of ­Pyridines

Qianlin Sun
,
Yuncong Luo
,
Xin Xu
We are grateful for the financial support provided by the National Natural Science Foundation of China (21871204).


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Abstract

The C–H borylation strategy has spurred intense research endeavors due to the high atom- and step-economy it represents and because of the broad range of utilities of the resulting organoboranes. Nevertheless, this powerful transformation has had limited substrate scope and poor regioselectivity when it was applied to Lewis basic substrates (e.g., azines). The basic functionalities in substrates can coordinate to the metal centers, hindering the formation of products. Herein, we provide a brief overview of recent advances in transition-metal-­catalyzed regioselective C–H borylation of pyridines. Attention is paid to the latest contributions, which have demonstrated remarkable ­regioselectivity.

1 Introduction

2 para-Selective C−H Borylation

3 meta-Selective C−H Borylation

4 ortho-Selective C−H Borylation

5 Summary



Publikationsverlauf

Eingereicht: 15. Juni 2022

Angenommen nach Revision: 03. Juli 2022

Accepted Manuscript online:
03. Juli 2022

Artikel online veröffentlicht:
29. Juli 2022

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