Synlett 2022; 33(19): 1879-1883
DOI: 10.1055/a-1908-2066
synpacts

Translation of a Phosphine- and Azide-Based Reaction to Chemical Modification of Biomolecules in Ionic Liquid

,
Jun Ohata
This work was financially supported by North Carolina State University.


Abstract

The difference of reaction design principles between traditional, small-molecule synthetic chemistry and biomolecular chemical reactions prevented the simple translation of small-molecule chemistry into biomolecular reactions. One of the key challenges of bioconjugation, or reactions on biomolecules, are the necessity of aqueous solutions as the solvent. In this Synpacts article, we describe our pursuit of using an ionic liquid as a nonaqueous reaction medium to conduct phosphine- and azide-based bioconjugation reactions.



Publication History

Received: 08 July 2022

Accepted after revision: 24 July 2022

Accepted Manuscript online:
24 July 2022

Article published online:
24 August 2022

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