Chiral Bicyclo[2.2.2]octane-Fused and Ferrocene-Derived Cyclopentadienyl Ligands for Asymmetric C–H Activation
Hao Liang
a
Key Laboratory of Bioinorganic and Synthetic Chemistry of Ministry of Education, School of Chemistry, Sun Yat-Sen University, Guangzhou, 510006, P. R. China
b
Guangdong Key Laboratory of Chiral Molecule and Drug Discovery, Sun Yat-Sen University, Guangzhou, 510006, P. R. China
,
Jun Wang∗
a
Key Laboratory of Bioinorganic and Synthetic Chemistry of Ministry of Education, School of Chemistry, Sun Yat-Sen University, Guangzhou, 510006, P. R. China
b
Guangdong Key Laboratory of Chiral Molecule and Drug Discovery, Sun Yat-Sen University, Guangzhou, 510006, P. R. China
› Author AffiliationsWe thank the National Natural Science Foundation of China for financial support (21971263).
To fulfill increasing and diverse demands of cyclopentadienyl metal complexes (CpM) catalyzed asymmetric C–H activation, innovation in developing new types of chiral Cp ligands should be important. In this context, we found the structurally rigid chiral bicyclo[2.2.2]octane-fused Cp ligands originated by Vollhardt and Halterman were efficient to enable highly enantioselective C–H activation of N-methoxybenzamides with quinones. Besides, we also designed and synthesized a class of ferrocene-based chiral Cp ligand featuring a loose chiral pocket, whose rhodium complexes exhibited high reactivity and reasonable enantioselectivity in an asymmetric intramolecular aryl amination of alkene.
1 Introduction
2 Chiral Cp Ligands Applied in Asymmetric C–H Activation
