Synlett 2023; 34(12): 1529-1533
DOI: 10.1055/a-2002-8680
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Special Issue Honoring Masahiro Murakami’s Contributions to Science

Total Syntheses of Dysidealactams E and F and Dysidealactone B, Drimane-Type Sesquiterpenes Derived from a Dysidea sp. of Marine Sponge

Yuhao Chen
a   Guangdong Key Laboratory for Research and the Development of Natural Drugs, The Marine Biomedical Research Institute, Guangdong Medical University, Zhanjiang, Guangdong, 524023, P. R. of China
,
Ping Lan
b   Institute for Advanced and Applied Chemical Synthesis, College of Pharmacy, Jinan University, Guangzhou, Guangdong 510632, P. R. of China
,
Lorenzo V. White
b   Institute for Advanced and Applied Chemical Synthesis, College of Pharmacy, Jinan University, Guangzhou, Guangdong 510632, P. R. of China
,
Weiguang Yang
a   Guangdong Key Laboratory for Research and the Development of Natural Drugs, The Marine Biomedical Research Institute, Guangdong Medical University, Zhanjiang, Guangdong, 524023, P. R. of China
,
a   Guangdong Key Laboratory for Research and the Development of Natural Drugs, The Marine Biomedical Research Institute, Guangdong Medical University, Zhanjiang, Guangdong, 524023, P. R. of China
b   Institute for Advanced and Applied Chemical Synthesis, College of Pharmacy, Jinan University, Guangzhou, Guangdong 510632, P. R. of China
› Institutsangaben
We thank the National Natural Science Foundation of China (Grant Nos. 22250410258 and 22250410259), the Science and Technology Planning Program of Zhanjiang (Grant. No. 2021A05247) and the Ministry of Science and Technology of the People’s Republic of China for financial support.


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Dedicated to Professor Masahiro Murakami (Kyoto University) in recognition of his profound and ingenious contributions to so many aspects of chemical synthesis.

Abstract

Dysidealactams E and F and dysidealactone B are recently reported marine natural products. Their syntheses from β-cyclocitral are detailed here. The preparation of certain derivatives and analogues of these compounds is also described and single-crystal X-ray analyses of two of these, as well as that of (±)-dysidealactam F, are reported.

Supporting Information



Publikationsverlauf

Eingereicht: 06. Dezember 2022

Angenommen nach Revision: 21. Dezember 2022

Accepted Manuscript online:
21. Dezember 2022

Artikel online veröffentlicht:
13. Februar 2023

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