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Int J Sports Med 2023; 44(09): 618-624
DOI: 10.1055/a-2035-8300
Review

The Association between ACTN3 R577X Polymorphism and Range of Motion: A Systematic Review and Meta-analysis

Mika Saito
1   Graduate School of Health and Sport Science, Nippon Sport Science University, Setagaya-ku, Japan
,
Hirofumi Zempo
2   Faculty of Health and Nutrition, Tokyo Seiei College, Katsushika-ku, Japan
,
Kathleen Yasmin de Almeida
1   Graduate School of Health and Sport Science, Nippon Sport Science University, Setagaya-ku, Japan
,
Hiroki Homma
1   Graduate School of Health and Sport Science, Nippon Sport Science University, Setagaya-ku, Japan
,
Naoki Kikuchi
1   Graduate School of Health and Sport Science, Nippon Sport Science University, Setagaya-ku, Japan
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Abstract

The R577X polymorphism in the α-actinin-3 gene (ACTN3) is associated with muscle strength and power; there is an association between ACTN3 R577X polymorphism and range of motion (ROM). We examined the effect of the ACTN3 R577X polymorphism on ROM through meta-analysis and systematic review. Relevant studies published before April 14, 2022 were identified from the PubMed database using the following keywords and Boolean operators: (“flexibility” or “Joint Range of Motion” or “Joint Flexibility” or “Range of motion”) and (“ACTN3” or “alpha-actinin 3”). Studies that met the following criteria were included: (1) published in English, (2) included human subjects, (3) provided ROM measurements, and (4) analyzed the ACTN3 R577X genotype. A total of 2908 participants from seven studies were included in the meta-analysis. The additive genetic model was assessed using a meta-regression model, and dominant and recessive models were analyzed using a random effects model. The ROM in the XX+RX genotype was significantly higher than that in the RR genotype (recessive model: p<0.001), and it increased additively in the order XX>RX>RR (additive model: p=0.029). However, no significant association was observed in the dominant model. These findings further elucidate the association between flexibility and the ACTN3 R577X genotype.

Key words

ACTN3 - α-actinin-3 - genotype - flexibility - ROM


Publication History

Received: 05 November 2022

Accepted: 14 February 2023

Accepted Manuscript online:
14 February 2023

Article published online:
02 May 2023

© 2023. Thieme. All rights reserved.

Georg Thieme Verlag
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

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