Photo-Induced Selective Difluoroalkylation of Unactivated Alkenes to Access Difluoroalkylated Indoles

Jinghui Tong; Renshi Luo; Liang Liu; Xiao Yang; Jianhua Liao

doi:10.1055/a-2039-5229

Synthesis, Table of Contents

Synthesis 2023; 55(12): 1875-1885
DOI: 10.1055/a-2039-5229

paper

Photo-Induced Selective Difluoroalkylation of Unactivated Alkenes to Access Difluoroalkylated Indoles

Jinghui Tong

^aSchool of Pharmacy, Gannan Medical University, Ganzhou 341000, Jiangxi Province, P. R. China

,

Renshi Luo

^aSchool of Pharmacy, Gannan Medical University, Ganzhou 341000, Jiangxi Province, P. R. China

^bCollege of Chemistry and Environmental Engineering, Shaoguan University, Shaoguan 512005, Guangdong Province, P. R. China

,

Liang Liu

^aSchool of Pharmacy, Gannan Medical University, Ganzhou 341000, Jiangxi Province, P. R. China

,

Xiao Yang

^aSchool of Pharmacy, Gannan Medical University, Ganzhou 341000, Jiangxi Province, P. R. China

,

Jianhua Liao∗

^aSchool of Pharmacy, Gannan Medical University, Ganzhou 341000, Jiangxi Province, P. R. China

^bCollege of Chemistry and Environmental Engineering, Shaoguan University, Shaoguan 512005, Guangdong Province, P. R. China

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Abstract

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Abstract

The difluoroalkylation of unactivated alkenes with ethyl iododifluoroacetate via visible light-induced process has been developed. This transformation provides selective access to difluoroalkylated indole derivatives in good yields depending on the choice of base, solvent, as well as the loading of ethyl iododifluoroacetate.

Key words

alkenes - cycloaddition - indoles - radical reaction - photooxidation

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References

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