Therapie des Typ-2-Diabetes

Rüdiger Landgraf; Jens Aberle; Andreas L. Birkenfeld; Baptist Gallwitz; Monika Kellerer; Harald H. Klein; Dirk Müller-Wieland; Michael A. Nauck; Tobias Wiesner; Erhard Siegel

doi:10.1055/a-2076-0024

Diabetologie und Stoffwechsel, Table of Contents

Diabetologie und Stoffwechsel 2023; 18(S 02): S162-S217
DOI: 10.1055/a-2076-0024

DDG-Praxisempfehlung

Therapie des Typ-2-Diabetes

Rüdiger Landgraf

¹Deutsche Diabetes Stiftung, Düsseldorf, Deutschland

,

Jens Aberle

²Sektion Endokrinologie und Diabetologie, Universitäres Adipositas-Zentrum Hamburg, Universitätsklinikum Hamburg-Eppendorf, Deutschland

,

Andreas L. Birkenfeld

³Deutsches Zentrum für Diabetesforschung (DZD e. V.), Neuherberg, Deutschland

,

Baptist Gallwitz

⁴Medizinische Klinik IV, Diabetologie, Endokrinologie, Nephrologie, Universitätsklinikum Tübingen, Deutschland

,

Monika Kellerer

⁵Zentrum für Innere Medizin I, Marienhospital Stuttgart, Deutschland

,

Harald H. Klein

⁶MVZ für Diagnostik und Therapie Bochum, Bergstraße 26, 44791 Bochum, Deutschland

,

Dirk Müller-Wieland

⁷Medizinische Klinik I, Universitätsklinikum RWTH Aachen, Aachen, Deutschland

,

Michael A. Nauck

⁸Sektion Diabetologie, Endokrinologie, Stoffwechsel, Med. Klinik I, St.-Josef-Hospital, Ruhr-Universität, Bochum, Deutschland

,

Tobias Wiesner

⁹MVZ Stoffwechselmedizin Leipzig, Leipzig, Deutschland

,

Erhard Siegel

¹⁰Abteilung für Innere Medizin – Gastroenterologie, Diabetologie/Endokrinologie und Ernährungsmedizin, St. Josefkrankenhaus Heidelberg GmbH, Heidelberg, Deutschland

› Author Affiliations

Abstract

Full Text

References

Literatur
1 Nationale VersorgungsLeitlinien. NVL-2-Diabetes – Teilpublikation, 3. Aufl. Mai 2023. Im Internet: www.leitlinien.de/themen/diabetes
2 Heidemann C, Christa Scheidt-NaveC. Prävalenz, Inzidenz und Mortalität von Diabetes mellitus bei Erwachsenen in Deutschland – Bestandsaufnahme zur Diabetes-Surveillance. Journal of Health Monitoring 2017; 2
3 Schmidt C, Reitzle L, Dreß J. et al. Prävalenz und Inzidenz des dokumentierten Diabetes mellitus – Referenzauswertung für die Diabetes-Surveillance auf Basis von Daten aller gesetzlich Krankenversicherten. Bundesgesundheitsbl 2020; 63: 93-102
4 Tönnies T, Rathmann W. Epidemiologie des Diabetes in Deutschland. In: Deutsche Diabetes Gesellschaft, diabetesDE – Deutsche Diabetes-Hilfe, Hrsg. Deutscher Gesundheitsbericht Diabetes 2022. Mainz: Verlag Kirchheim; 2021: 9-15
5 Tönnies T, Hoyer A, Brinks R. et al. Spatio-temporal trends in the incidence of type 2 diabetes in Germany—analysis of the claims data of 63 million persons with statutory health insurance from 2014 to 2019. Dtsch Arztebl Int 2023; 120: 173-179
6 Tönnies T, Hoyer A, Brinks R. et al. Spatio-temporal trends in the incidence of type 2 diabetes in Germany—analysis of the claims data of 63 million persons with statutory health insurance from 2014 to 2019. Dtsch Arztebl Int 2023; 120: 173-179
7 Rosengren A, Dikaiou P. Cardiovascular outcomes in type 1 and type 2 diabetes. Diabetologia 2023; 66: 425-437
8 Dziopa K, Asselbergs FW, Gratton J. et al. Cardiovascular risk prediction in type 2 diabetes: a comparison of 22 risk scores in primary care settings. Diabetologia 2022; 65: 644-656
9 Alberti KGMM, Eckel RH, Grundy SM. et al. Harmonizing the Metabolic Syndrome. Circulation 2009; 120: 1640-1645
10 Heinemann L, Kaiser P, Freckmann G. et al. HbA1c-Messung in Deutschland: Ist die Qualität ausreichend für Verlaufskontrolle und Diagnose?. Diabetologie 2018; 13: 46-53
11 Landgraf R, Nauck M, Freckmann G. et al. Fallstricke bei der Diabetesdiagnostik: Wird zu lax mit Laborwerten umgegangen?. Dtsch Med Wochenschr 2018; 143: 1549-1555
12 Pleus S, Tytko A, Landgraf R. et al. Definition, Klassifikation, Diagnostik und Differenzialdiagnostik des Diabetes mellitus: Update 2023. Diabetol Stoffwechs 2023; 18 (Suppl. 02) S100-S113
13 Landgraf R. HbA1c in der Diabetesdiagnostik. Der Goldstandard?. Diabetes aktuell 2021; 19: 22-29
14 Ahlqvist E, Storm P, Käräjämäki A. et al. Novel subgroups of adult-onset diabetes and their association with outcomes: a data-driven cluster analysis of six variables. Lancet Diabetes Endocrinol 2018; 6: 361-369
15 Zaharia OP, Strassburger K, Strom A. German Diabetes Study Group. et al. Risk of diabetes-associated diseases in subgroups of patients with recentonset diabetes: a 5-year follow-up study. Lancet Diabetes Endocrinol 2019; 7: 684-694
16 Dennis JM, Shields BM, Henley WE. et al. Disease progression and treatment response in data-driven subgroups of type 2 diabetes compared with models based on simple clinical features: an analysis using clinical trial data. Lancet Diabetes Endocrinol 2019; 7: 442-451
17 Elwyn G, Vermunt NPCA. Goal-based shared decision-making: developing an integrated model. J Patient Exp 2020; 7: 688-696
18 Wang R, Song Y, Yan Y. et al. Elevated serum uric acid and risk of cardiovascular or all-cause mortality in people with suspected or definite coronary artery disease: A meta-analysis. Atherosclerosis 2016; 254: 193-199
19 Mach F, Baigent C, Catapano AL. et al. for the ESC Scientific Document Group. 2019 ESC/EAS Guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk. Eur Heart J 2020; 41: 111-188
20 Parhofer KG, Birkenfeld AL, Krone W. et al. Lipidtherapie bei Patienten mit Diabetes mellitus. Diabetol Stoffwechs 2023; 18 (Suppl. 02) S330-S336
21 Jordan J, Kurschat C, Reuter H. Arterielle Hypertonie. Diagnostik und Therapie. Dtsch Arztebl Int 2018; 115: 557-568
22 Whelton PK, Carey RM, Aronow WS. et al. ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: Executive Summary: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. J Am Coll Cardiol 2018; 71: 2199-2269
23 Williams B, Mancia G, Spiering W. et al. 2018 ESC/ESH Guidelines for the management of arterial hypertension. Eur Heart J 2018; 39: 3021-3104
24 Nationale Versorgungs-Leitlinien. Hypertonie. Version 1.0, AWMF-Register-Nr. nvl-009. Im Internet: https://www.leitlinien.de/themen/hypertonie
25 Han H, Cao Y, Feng C. et al. Association of a Healthy Lifestyle With All-Cause and Cause-Specific Mortality Among Individuals With Type 2 Diabetes: A Prospective Study in UK Biobank. Diabetes Care 2022; 45: 319-329
26 Zhang Y, Pan XF, Chen J. et al. Combined lifestyle factors and risk of incident type 2 diabetes and prognosis among individuals with type 2 diabetes: a systematic review and meta-analysis of prospective cohort studies. Diabetologia 2020; 63: 21-3316
27 Kivimäki M, Bartolomucci A, Kawachi I. The multiple roles of life stress in metabolic disorders. Nat Rev Endocrinol 2023; 19: 10-27
28 Lloyd-Jones DM, Allen NB, Anderson CAM. et al. Life’s Essential 8: Updating and Enhancing the American Heart Association’s Construct of Cardiovascular Health: A Presidential Advisory From the American Heart Association. Circulation 2022; 146: e18-e43
29 Nationale VersorgungsLeitlinie (NVL) Diabetes – Strukturierte Schulungsprogramme 2018. Im Internet: www.leitlinien.de/nvl/diabetes/schulungsprogramme
30 Hermanns N, Ehrmann D, Shapira A. et al. Coordination of glucose monitoring, self-care behaviour and mental health: achieving precision monitoring in diabetes. Diabetologia 2022; 65: 1883-1894
31 Sherr JL, Heinemann L, Fleming A. et al. Automated insulin delivery: benefits, challenges, and recommendations. A Consensus Report of the Joint Diabetes Technology Working Group of the European Association for the Study of Diabetes and the American Diabetes Association. Diabetologia 2023; 66: 3-22
32 Oliver N, Chow E, Luk AOY. et al. Applications of continuous glucose monitoring across settings and populations: Report from the 23^rd Hong Kong diabetes and cardiovascular risk factors—East meets west symposium. Diabetic Medicine 2023; 40: e15038
33 Daly A, Howorka R. Technology in the management of type 2 diabetes – present status and future prospects. Diabetes Obes Metab 2021; 23: 1722-1732
34 Di Molfetta S, Caruso I, Cignarelli A. et al. Professional continuous glucose monitoring in patients with diabetes mellitus: A systematic review and meta-analysis. Diabetes Obes Metab 2023; 25: 1301-1310
35 Forouhi NG, Misra A, Mohan V. et al. Dietary and nutritional approaches for prevention and management of type 2 diabetes. BMJ 2018; 361: k2234
36 Serra-Majem L, Román-Viñas B, Sanchez-Villegas A. et al. Benefits of the Mediterranean diet: Epidemiological and molecular aspects. Mol Aspects Med 2019; 67: 1-55
37 Taylor R, Al-Mrabeh A, Sattar N. Understanding the mechanisms of reversal of type 2 diabetes. Lancet Diabetes Endocrinol 2019; 7: 726-736
38 Evert AB, Dennison M, Gardner CD. et al. Nutrition therapy for adults with Diabetes or prediabetes: a consensus report. Diabetes Care 2019; 42: 731-754
39 Hauner H. Evidenz in der Ernährungstherapie des Diabetes mellitus. Diabetologe 2021; 17: 687-696
40 Tombeck A. Rolle der Ballaststoffe in der Ernährung von Menschen mit Typ-2-Diabetes. Info Diabetologie 2023; 17: 31-36
41 Carlström M, Larsson SC. Coffee consumption and reduced risk of developing type 2 diabetes: a systematic review with meta-analysis. Nutr Rev 2018; 76: 395-417
42 Di Maso M, Boffetta P, Negri E. et al. Caffeinated Coffee Consumption and Health Outcomes in the US Population: A Dose–Response Meta-Analysis and Estimation of Disease Cases and Deaths Avoided. Adv Nutr 2021; 12: 1160-1176
43 Larsson SC, Woolf B, Gill D. Appraisal of the causal effect of plasma caffeine on adiposity, type 2 diabetes, and cardiovascular disease: two sample mendelian randomisation study. BMJ Med 2023; 2: e000335
44 Chester B, Babu JR, Greene MW. et al. The effects of popular diets on type 2 diabetes management. Diabetes Metab Res Rev 2019; 35: e3188
45 Naude CE, Brand A, Schoonees A. et al. Low-carbohydrate versus balanced carbohydrate diets for reducing weight and cardiovascular risk (Review). Cochrane Database Syst Rev 2022; 1: CD013334
46 Patikorn C, Roubal K, Sajesh KV. et al. Intermittent Fasting and Obesity-Related Health Outcomes. An Umbrella Review of Meta-analyses of Randomized Clinical Trials. JAMA Netw Open 2021; 4: e2139558
47 Uldal S, Clemmensen KKB, Persson F. et al. Is Time-Restricted Eating Safe in the Treatment of Type 2 Diabetes? A Review of Intervention Studies. Nutrients 2022; 14: 2299
48 Shan Z, Wang F, Li Y. et al. Healthy Eating Patterns and Risk of Total and Cause-Specific Mortality. JAMA Intern Med 2023; 183: 142-153
49 Churuangsuk C, Hall J, Reynolds A. et al. Diets for weight management in adults with type 2 diabetes: an umbrella review of published meta-analyses and systematic review of trials of diets for diabetes remission. Diabetologia 2022; 65: 14-36
50 The Diabetes and Nutrition Study Group (DNSG) of the European Association for the Study of Diabetes (EASD). Evidence-based European recommendations for the dietary management of diabetes. Diabetologia 2023; 66: 965-985
51 Salas-Salvadó J, Díaz-López A, Ruiz-Canela M. et al. Effect of a Lifestyle Intervention Program With Energy-Restricted Mediterranean Diet and Exercise on Weight Loss and Cardiovascular Risk Factors: One-Year Results of the PREDIMED-Plus Trial. Diabetes Care 2019; 42: 777-788
52 Thackrey E, Chen J, Martino CR. et al. The effects of diet on weight and metabolic outcomes in patients with double diabetes: A systematic review. Nutrition 2022; 94: 111536
53 Kempf K, Altpeter B, Berger J. et al. Efficacy of the telemedical lifestyle intervention program TeLiPro in advanced stages of type 2 diabetes: A randomized controlled trial. Diabetes Care 2017; 40: 863-871
54 Lean MEJ, Leslie WS, Barnes AC. et al. Durability of a primary care-led weight-management intervention for remission of type 2 diabetes: 2-year results of the DiRECT open-label, cluster-randomized trial. Lancet Diabetes Endocrinol 2019; 7: 344-355
55 Adipositas – Prävention und Therapie. AWMF-Register Nr. 050-001.
56 Cassidy S, Trenell M, Stefanetti RJ. et al. Physical activity, inactivity and sleep during the Diabetes Remission Clinical Trial (DiRECT). Diabetic Medicine 2023; 40: e15010
57 Aberle J, Lautenbach A, Meyhöfer S. et al. Adipositas und Diabetes. Diabetol Stoffwechs 2023; 18 (Suppl. 02) S305-S313
58 Yang D, Yang Y, Li Y. et al. Physical exercise as therapy for type 2 diabetes mellitus: from mechanism to orientation. Ann Nutr Metab 2019; 74: 313-321
59 Tarp J, Støle AP, Blond K. et al. Cardiorespiratory fitness, muscular strength and risk of type 2 diabetes: a systematic review and metaanalysis. Diabetologia 2019; 62: 1129-1142
60 Liu Y, Ye W, Chen Q. et al. Resistance exercise intensity is correlated with attenuation of HbA1c and insulin in patients with type 2 diabetes: A systematic review and meta-analysis. Int J Environ Res Public Health 2019; 16: 140
61 Kanaley JA, Colberg SR, Corcoran MH. et al. Exercise/Physical Activity in Individuals with Type 2 Diabetes: A Consensus Statement from the American College of Sports Medicine. Med Sci Sports Exerc 2022; 54: 353-368
62 Esefeld K, Kress S, Behrens M. et al. Diabetes, Sport und Bewegung. Diabetol Stoffwechs 2021; 16 (Suppl. 02) S299-S307
63 Jabardo-Camprubí G, Donat-Roca R, Sitjà-Rabert M. et al. Drop-out ratio between moderate to high-intensity physical exercise treatment by patients with, or at risk of, type 2 diabetes mellitus: A systematic review and meta-analysis. Physiol Behav 2020; 215: 112786
64 Villafranca Cartagena M, Tort-Nasarre G, Rubinat ArnaldoE. Barriers and Facilitators for Physical Activity in Adults with Type 2 Diabetes Mellitus: A Scoping Review. Int J Environ Res Public Health 2021; 18: 5359
65 MacDonald CS, Ried-Larsen M, Soleimani J. et al. A systematic review of adherence to physical activity interventions in individuals with type 2 diabetes. Diabetes Metab Res Rev 2021; 37: e3444
66 Thomsen S, Kristensen GDW, Jensen NWH. et al. Maintaining changes in physical activity among type 2 diabetics – A systematic review of rehabilitation interventions. Scand J Med Sci Sports 2021; 31: 1582-1591
67 Pan A, Wang Y, Talaei M. et al. Relation of active, passive, and quitting smoking with incident diabetes: a meta-analysis and systematic review. Lancet Diabetes Endocrinol 2015; 3: 958-996
68 Kar D, Gillies C, Nath M. et al. Association of smoking and cardiometabolic parameters with albuminuria in people with type 2 diabetes mellitus: a systematic review and meta-analysis. Acta Diabetol 2019; 56: 839-850
69 Rauchen und Tabakabhängigkeit: Screening, Diagnostik und Behandlung. S3-Leitlinie Langversion AWMF-Register Nr. 076-006.
70 Tabakatlas Deutschland 2020. Im Internet: www.dkfz.de/de/tabakkontrolle/download/Publikationen/sonstVeroeffentlichungen/Tabakatlas-Deutschland-2020_dp.pdf
71 Concato J, Corrigan-Curay J. Real-World Evidence – Where Are We Now?. N Engl J Med 2022; 386: 1680-1682
72 Fleming GA, Petrie JR, Bergenstal RM. et al. Diabetes Digital App Technology: Benefits, Challenges, and Recommendations. A Consensus Report by the European Association for the Study of Diabetes (EASD) and the American Diabetes Association (ADA) Diabetes Technology Working Group. Diabetes Care 2020; 43: 250-260
73 Khunti K, Gomes MB, Pocock S. et al. Therapeutic inertia in the treatment of hyperglycaemia in patients with type 2 diabetes: A systematic review. Diabetes Obes Metab 2018; 20: 427-437
74 Matthews DR, Paldánius PM, Proot P. VERIFY study group et al. Glycaemic durability of an early combination therapy with vildagliptin and metformin versus sequential metformin monotherapy in newly diagnosed type 2 diabetes (VERIFY): a 5-year, multicentre, randomized, double-blind trial. Lancet 2019; 394: 1519-1529
75 Meier JJ. Efficacy of Semaglutide in a Subcutaneous and an Oral Formulation. Front Endocrinol 2021; 12: 645617
76 Gallwitz B, Giorgino F. Clinical Perspectives on the Use of Subcutaneous and Oral Formulations of Semaglutide. Front Endocrinol 2021; 12: 645507
77 Zaazouee MS, Hamdallah A, Helmy SK. et al. Semaglutide for the treatment of type 2 Diabetes Mellitus: A systematic review and network meta-analysis of safety and efficacy outcomes. Diabetes Metab Syndr 2022; 16: 102511
78 Alhindi Y, Avery A. The efficacy and safety of oral semaglutide for glycaemic management in adults with type 2 diabetes compared to subcutaneous semaglutide, placebo, and other GLP-1 RA comparators: A systematic review and network meta-analysis. Contemp Clin Trials Commun 2022; 28: 100944
79 Gough SC, Bode B, Woo V. et al. Efficacy and safety of a fixed-ratio combination of insulin degludec and liraglutide (IDegLira) compared with its components given alone: results of a phase 3, open-label, randomised, 26-week, treat-to-target trial in insulin-naive patients with type 2 diabetes. Lancet Diabet Endocrinol 2014; 2: 885-893
80 Diamant M, Nauck MA, Shaginian R. et al. Glucagon-like peptide 1 receptor agonist or bolus insulin with optimized basal insulin in type 2 diabetes. Diabetes Care 2014; 37: 2763-2773
81 Montvida O, Klein K, Kumar S. et al. Addition of or switch to insulin therapy in people treated with glucagon-like peptide-1 receptor agonists: A real-world study in 66 583 patients. Diabetes Obes Metab 2017; 19: 108-117
82 Gomez-Peralta F, Al-Ozairi E, Jude EB. et al. Titratable fixed-ratio combination of basal insulin plus a glucagon-like peptide-1 receptor agonist: A novel, simplified alternative to premix insulin for type 2 diabetes. Diabetes Obes Metab 2021; 23: 1445-1452
83 Edelman S, Cassarino D, Kayne D. et al. Treatment persistence and adherence in people with type 2 diabetes switching to iGlarLixi vs free-dose combinations of basal insulin and glucagon-like peptide 1 receptor agonist. J Manag Care Spec Pharm 2022; 28: 958-968
84 Champlain JM. Practical Considerations for Use of Insulin/Glucagon-Like Peptide 1 Receptor Agonist Combinations in Older Adults With Type 2 Diabetes. J Fam Pract 2022; 71 (06) S34-S39
85 Mehta R, Billings LK, Liebl A. et al. Transitioning from basal-bolus or premix insulin therapy to a combination of basal insulin and glucagon-like peptide-1 receptor agonist in people with type 2 diabetes. Diabet Med 2022; 39: e14901
86 Risovic I, Dumanovic MS, Bojic M. et al. Direct comparison two fixed-ratio combination glucagon-like peptide receptor agonist and basal insulin on glycemic and non glycemic parameters in type 2 diabetes. BMC Endocr Disord 2023; 23: 28
87 Home PD, McCrimmon RJ, Rosenstock J. et al. SoliMix trial investigators. Findings for iGlarLixi versus BIAsp 30 confirmed in groups of people with type 2 diabetes with different biomedical characteristics.. Diabetes Obes Metab 2023; 25: 656-663
88 Visolyi GÁ, Domján BA, Svébis MM. et al. Comparison of Efficacy and Safety of Commercially Available Fixed-Ratio Combinations of Insulin Degludec/Liraglutide and Insulin Glargine/Lixisenatide: A Network Meta-analysis. Can J Diabetes 2023; 47: 368-377
89 Daly AB, Boughton CK, Nwokolo M. et al. Fully automated closed-loop insulin delivery in adults with type 2 diabetes: an open-label, single-center, randomized crossover trial. Nat Med 2023; 29: 203-208
90 Karol AB, OʼMalley G, Fallurin R. et al. Automated Insulin Delivery Systems as a Treatment for Type 2 Diabetes Mellitus: A Review. Endocr Pract 2023; 29: 214-220
91 Davis GM, Peters AL, Bode BW. et al. Safety and Efficacy of the Omnipod 5 Automated Insulin Delivery System in Adults With Type 2 Diabetes: From Injections to Hybrid Closed-Loop Therapy. Diabetes Care 2023; 46: 742-750
92 Averna M, Catapano AL. One year after the ESC/EAS guidelines on cholesterol control. Whatʼs the new evidence? Whatʼs missing?. Eur J Intern Med 2022; 95: 1-4
93 Mengden T, Weisser B. Therapieüberwachung bei arterieller Hypertonie. Dtsch Ärztebl 2021; 118: 473-478
94 Banegas JR, Ruilope LM, de la Sierra A. et al. Relationship between clinic and ambulatory blood-pressure measurements and mortality. N Engl J Med 2018; 378: 1509-1520
95 ESC/ESH Guidelines 2018. Management der arteriellen Hypertonie. Im Internet: www.dgk.de
96 American Diabetes Association. Cardiovascular Disease and Risk Management: Standards of Medical Care in Diabetes – 2021. Diabetes Care 2021; 44 (Suppl. 01) S125-S150
97 The SPRINT Research Group. A randomized trial of intensive versus standard blood-pressure control. N Engl J Med 2015; 373: 2103-2116
98 The SPRINT Research Group. Final Report of a Trial of Intensive versus Standard Blood-Pressure Control. N Engl J Med 2021; 384: 1921-1930
99 Busch M, Wanner C, Wolf G. KDIGO-Leitlinie zur Behandlung des Diabetes mellitus bei chronischer Nierenerkrankung – Update 2022. Nephrologie 2023; 18: 160-170
100 ElSayed NA, Aleppo G, Aroda VR. et al. Chronic Kidney Disease and Risk Management: Standards of Care in Diabetes – 2023. Diabetes Care 2023; 46 (Suppl. 01) S191-S202
101 Merker L, Bautsch BW, Ebert T. et al. Nephropathie bei Diabetes. Diabetol Stoffwechs 2023; 18 (Suppl. 02) S342-S347
102 The Nuffield Department of Population Health Renal Studies Group* and the SGLT2 inhibitor Meta-Analysis Cardio-Renal Trialists’ Consortium. Impact of diabetes on the effects of sodium glucose co-transporter-2 inhibitors on kidney outcomes: collaborative meta-analysis of large placebo-controlled trials. Lancet 2022; 400: 1788-1801
103 Neuen BL, Young T, Heerspink HJL. et al. SGLT2 inhibitors for the prevention of kidney failure in patients with type 2 diabetes: a systematic review and meta-analysis. Lancet Diabetes Endocrinol 2019; 7: 845-854
104 Giugliano D, Longo M, Signoriello S. et al. The effect of DPP-4 inhibitors, GLP-1 receptor agonists and SGLT-2 inhibitors on cardiorenal outcomes: a network meta-analysis of 23 CVOTs. Cardiovasc Diabetol 2022; 21: 42
105 Mannucci E, Gallo M, Giaccari A. et al. Effects of glucose-lowering agents on cardiovascular and renal outcomes in subjects with type 2 diabetes: An updated meta-analysis of randomized controlled trials with external adjudication of events. Diabetes Obes Metab 2023; 25: 444-453
106 Zhang Y, Jiang L, Wang J. et al. Network meta-analysis on the effects of finerenone versus SGLT2 inhibitors and GLP-1 receptor agonists on cardiovascular and renal outcomes in patients with type 2 diabetes mellitus and chronic kidney disease. Cardiovasc Diabetol 2022; 21: 232
107 Singh AK, Singh A, Singh R. et al. Finerenone in diabetic kidney disease: A systematic review and critical appraisal. Diabetes Metab Syndr 2022; 16: 102638
108 Shi Q, Nong K, Vandvik PO. et al. Benefits and harms of drug treatment for type 2 diabetes: systematic review and network meta-analysis of randomised controlled trials. BMJ 2023; 381: e074068
109 Stefan N, Roden M. Diabetes und Fettleber. Diabetol Stoffwechs 2023; 18 (Suppl. 02) S324-S329
110 Roeb E, Canbay A, Bantel H. et al. Aktualisierte S2k-Leitlinie Nicht-alkoholische Fettlebererkrankung der Deutschen Gesellschaft für Gastroenterologie, Verdauungs- und Stoffwechselkrankheiten (DGVS) April 2022 – AWMF-Registernummer: 021–025.