Electrosynthesis of Quinoxalines via Intermolecular Cyclization/Dehydrogenation of Ketones with o-Phenylenediamines

Abstract

In this study, we proposed a novel electrochemical dehydrogenative synthetic method for preparing 2-substituted quinoxalines by intermolecular cyclization of aryl alkyl ketones and o-phenylenediamines. This method gave various quinoxalines in yields ranging from 35% to 71%. This novel protocol employs mild reaction conditions and offers moderate to excellent yields, a wide substrate scope, and broad functional-group compatibility. Furthermore, a late-stage functionalization and the wide substrate scope demonstrated the synthetic utility of this protocol.

Key words

quinoxalines - electrochemistry - cyclization - green chemistry - dehydrogenation

Publication History

Received: 15 May 2024

Accepted after revision: 29 May 2024

Accepted Manuscript online:
05 June 2024

Article published online:
14 June 2024

• References and Notes

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