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Synlett
DOI: 10.1055/a-2388-9578
letter
Special Issue to Celebrate the 75th Birthday of Prof. B. C. Ranu

Sustainable N-Formylation of Anilines: Harnessing Aleuritic Acid as a Renewable Formyl Source

Hetavi A. Vadariya
a   Academy of Scientific & Innovative Research (AcSIR), Ghaziabad, 201002, India
b   CSIR–Central Salt & Marine Chemicals Research Institute, G. B. Marg, Bhavnagar-364002, Gujarat, India
,
Gaurav Badhani
a   Academy of Scientific & Innovative Research (AcSIR), Ghaziabad, 201002, India
b   CSIR–Central Salt & Marine Chemicals Research Institute, G. B. Marg, Bhavnagar-364002, Gujarat, India
,
B. Mohamed Farves
b   CSIR–Central Salt & Marine Chemicals Research Institute, G. B. Marg, Bhavnagar-364002, Gujarat, India
,
Krupa N. Boda
b   CSIR–Central Salt & Marine Chemicals Research Institute, G. B. Marg, Bhavnagar-364002, Gujarat, India
,
Subbarayappa Adimurthy  ∗
a   Academy of Scientific & Innovative Research (AcSIR), Ghaziabad, 201002, India
b   CSIR–Central Salt & Marine Chemicals Research Institute, G. B. Marg, Bhavnagar-364002, Gujarat, India
› Author AffiliationsH.A.V. is thankful to the Department of Science and Technology (DST), Ministry of Science and Technology, India, for the award of INSPIRE Fellowship and G.B. is thankful to the University Grants Commission, New Delhi, India for the award of Senior Research Fellowship. We are also thankful to the Central Salt and Marine Chemicals Research Institute, Council of Scientific and Industrial Research (CSIR-CSMCRI, MLP-074 and HCP-049) for partial financial support.
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Dedicated to Professor B. C. Ranu on the occasion of his 75th birthday celebration

Abstract

N-Formylation of anilines using a renewable aleuritic acid as an eco-friendly and sustainable formylating source has been developed. para-Substituted anilines generally provided good yields, while moderate yields were observed with meta- and ortho-substituted derivatives. In situ generated formic acid through oxidative cleavage of aleuritic acid serve as a formyl source, which has been confirmed through control experiments.

Key words

aleuritic acid - amines - amides - formylation

Supporting Information

    Supporting information for this article is available online at https://doi.org/10.1055/a-2388-9578.
  • Supporting Information


Publication History

Received: 27 June 2024

Accepted after revision: 15 August 2024

Accepted Manuscript online:
15 August 2024

Article published online:
18 September 2024

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