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Synthesis
DOI: 10.1055/a-2389-4411
DOI: 10.1055/a-2389-4411
review
Advances in Transition-Metal Catalysis and Organocatalysis Approaches towards Asymmetric Synthesis of β-Amino Acid Derivatives
We thank the National Natural Science Foundation of China (21971103), the Guangdong Provincial Department of Science and Technology (2019CX01Y251), the Shenzhen Science and Technology Innovation Commission (JCYJ20200109141408054), and the Guangdong Provincial Key Laboratory of Catalysis (2020B121201002) for financial support.
Abstract
The stereoselective synthesis of β-amino acids has attracted major attention among the synthetic community in recent years. This review provides an overview of the important advances in chiral β-amino acid synthesis over the past decade. It covers the development of enantioselective methods using transition-metal complexes or organocatalysts, mainly including catalytic asymmetric hydrogenation, the Mannich reaction, multicomponent reactions of diazo compounds, and conjugate addition. Additionally, the asymmetric synthesis of optically active β-amino acids by other approaches are also summarized.
1 Introduction
2 Strategies towards the Asymmetric Synthesis of β-Amino Acids
2.1 Hydrogenation
2.2 Mannich Reaction
2.3 Conjugate Addition
2.4 Multicomponent Reactions
2.5 Miscellaneous
2.5.1 Synthesis of β-Amino Acids from Chiral Amines
2.5.2 Synthesis of β-Amino Acids from Isoxazolidinones
2.5.3 Synthesis of β-Amino Acids by Other Methodologies
3 Summary and Outlook
Key words
asymmetric synthesis - β-amino acids - transition-metal catalysis - organocatalysis - chiral ligandsPublication History
Received: 17 July 2024
Accepted after revision: 15 August 2024
Accepted Manuscript online:
16 August 2024
Article published online:
30 September 2024
© 2024. Thieme. All rights reserved
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