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Synthesis
DOI: 10.1055/a-2435-5669
DOI: 10.1055/a-2435-5669
short review
SuFEx Chemistry
The First Decade of SuFEx Chemistry: Advancements in SuFEx Polymerization, Non-Canonical SuFEx Reactions, and SuFEx Radiochemistry
Min Pyeong Kim‡
a
Department of Chemistry, Department of Chemical Engineering, and Graduate School of Carbon Neutrality, Ulsan National Institute of Science and Technology (UNIST), Ulsan 44919, Republic of Korea
,
Manoj Kumar Sahoo‡
a
Department of Chemistry, Department of Chemical Engineering, and Graduate School of Carbon Neutrality, Ulsan National Institute of Science and Technology (UNIST), Ulsan 44919, Republic of Korea
b
Center for Genomic Integrity, Institute for Basic Science, Ulsan 44919, Republic of Korea
,
Joong-Hyun Chun∗
c
Department of Nuclear Medicine, Yonsei University College of Medicine, Seoul 03722, Republic of Korea
,
a
Department of Chemistry, Department of Chemical Engineering, and Graduate School of Carbon Neutrality, Ulsan National Institute of Science and Technology (UNIST), Ulsan 44919, Republic of Korea
b
Center for Genomic Integrity, Institute for Basic Science, Ulsan 44919, Republic of Korea
› InstitutsangabenThis work was supported by the National Research Foundation of Korea (NRF) grants funded by the Korea government (MSIT) (No. NRF-2020R1A5A1019631, NRF-2022R1A2C2004064) and by the Alchemist grant funded by the Ministry of Trade, Industry & Energy (20025719). Dr. Sahoo thanks the support by the Institute for Basic Science (IBS-R022-D1).
Abstract
This year marks the 10th anniversary of SuFEx chemistry, a field that has witnessed significant advancements over the past decade. These include efficient synthetic strategies toward polymerization via the SuFEx approach leading to diverse polymers, alongside the discovery of new SuFExable hubs and coupling conditions. Non-canonical reactions, such as deoxyfluorination and on-water reactions, have also emerged. Furthermore, there have been substantial strides in the radiosynthesis of [18F] SuFExable hubs. This review provides an overview of these developments, focusing on polymerization, non-canonical reaction, and radiochemistry in SuFEx chemistry.
1 Introduction
2 SuFEx Polymerization
3 Non-Canonical SuFEx Reactions
4 Fluorine-18 SuFEx Radiochemistry
5 Conclusions and Outlook
Key words
SuFEx chemistry - polymerization - polymer degradation - deoxyhalogenation - radiofluorinationPublikationsverlauf
Eingereicht: 07. August 2024
Angenommen nach Revision: 07. Oktober 2024
Accepted Manuscript online:
07. Oktober 2024
Artikel online veröffentlicht:
11. November 2024
© 2024. Thieme. All rights reserved
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