Synergistic Pd/Cu-Catalyzed Asymmetric Csp3–Csp3 Coupling of 1,3-Dienes with 2-Acylimidazoles

Mingze Wang; Weiwei Zi

doi:10.1055/a-2457-0319

Synthesis, Table of Contents

Synthesis 2025; 57(05): 1025-1033
DOI: 10.1055/a-2457-0319

paper

Dual Catalysis

Synergistic Pd/Cu-Catalyzed Asymmetric Csp³–Csp³ Coupling of 1,3-Dienes with 2-Acylimidazoles

Mingze Wang

^aState Key Laboratory and Institute of Elemento-Organic Chemistry, College of Chemistry, Frontiers Science Center for New Organic Matter, Nankai University, Tianjin 300071, P. R. of China

,

Weiwei Zi∗

^aState Key Laboratory and Institute of Elemento-Organic Chemistry, College of Chemistry, Frontiers Science Center for New Organic Matter, Nankai University, Tianjin 300071, P. R. of China

^bHaihe Laboratory of Sustainable Chemical Transformations, Tianjin 300071, P. R. of China

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Abstract

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Abstract

The catalytic asymmetric coupling of 1,3-dienes with carbon nucleophiles is an important process for forming Csp³–Csp³ bonds. Here, we describe a synergistic Pd/Cu-catalyzed coupling of 1,3-dienes with 2-acylimidazoles. This reaction produces 2-acylimidazole derivatives that have α,β-adjacent stereocenters in moderate yields with good to excellent stereoselectivity.

Key words

synergistic catalysis - palladium - copper - Csp³–Csp³ coupling - 2-acylimidazoles - 1,3-dienes

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References

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Supplementary Material