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CC BY-NC-ND 4.0 · Endosc Int Open 2025; 13: a24749966
DOI: 10.1055/a-2474-9966
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Ingestible sensor capsule with extended battery capacity allows early diagnosis of GI malignancy in comorbid patients with occult bleeding and anemia

Oscar Cahyadi 
1   Ruhr University Bochum, Bochum, Germany (Ringgold ID: RIN9142)
2   Department of Gastroenterology, Katholisches Klinikum Bochum Sankt Josef-Hospital, Bochum, Germany (Ringgold ID: RIN91789)
,
Peter Ewald
2   Department of Gastroenterology, Katholisches Klinikum Bochum Sankt Josef-Hospital, Bochum, Germany (Ringgold ID: RIN91789)
,
Daniel Quast
1   Ruhr University Bochum, Bochum, Germany (Ringgold ID: RIN9142)
2   Department of Gastroenterology, Katholisches Klinikum Bochum Sankt Josef-Hospital, Bochum, Germany (Ringgold ID: RIN91789)
,
Keith Siau 
3   Gastroenterology, Royal Cornwall Hospitals NHS Trust, Truro, United Kingdom of Great Britain and Northern Ireland (Ringgold ID: RIN8028)
4   Immunology and Immunotherapy, University of Birmingham College of Medical and Dental Sciences, Birmingham, United Kingdom of Great Britain and Northern Ireland (Ringgold ID: RIN150183)
,
Waldemar Uhl
1   Ruhr University Bochum, Bochum, Germany (Ringgold ID: RIN9142)
5   Department of Surgery, Katholisches Klinikum Bochum Sankt Josef-Hospital, Bochum, Germany (Ringgold ID: RIN91789)
,
Wolfgang Schmidt
1   Ruhr University Bochum, Bochum, Germany (Ringgold ID: RIN9142)
2   Department of Gastroenterology, Katholisches Klinikum Bochum Sankt Josef-Hospital, Bochum, Germany (Ringgold ID: RIN91789)
,
Christian Torres Reyes
1   Ruhr University Bochum, Bochum, Germany (Ringgold ID: RIN9142)
2   Department of Gastroenterology, Katholisches Klinikum Bochum Sankt Josef-Hospital, Bochum, Germany (Ringgold ID: RIN91789)
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Abstract

HemoPill is a commercially available ingestible electronic capsule that detects hematin and blood through photometric measurements. An examination with HemoPill requires no special preparation and can be done bedside. Its major advantage is noninvasive luminal blood detection, requiring only a small amount of blood or hematin (> 20 mL) for a positive result, making it especially suitable in multimorbid and/or geriatric patients not primarily fit for endoscopic diagnostic allowing rapid and uncomplicated bleeding detection.

Recent clinical reports showed that HemoPill is useful in stratifying patients with anemia and bleeding in the setting of an Emergency Department. The second generation with an extended battery capacity of 9 hours opens the possibility of detecting blood in the middle and lower gastrointestinal tract.

Herein we report another advantage of the extended battery capacity allowing noninvasive bleeding detection in the middle and lower gastrointestinal tract, leading to early endoscopic diagnosis of gastrointestinal malignancies with occult bleeding in comorbid patients with severe anemia.

Keywords

Endoscopy Small Bowel - Small intestinal bleeding - Capsule endoscopy - Small bowel endoscopy


Publication History

Received: 23 July 2024

Accepted after revision: 07 October 2024

Accepted Manuscript online:
18 November 2024

Article published online:
07 January 2025

© 2025. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).

Georg Thieme Verlag KG
Oswald-Hesse-Straße 50, 70469 Stuttgart, Germany

Bibliographical Record
Oscar Cahyadi, Peter Ewald, Daniel Quast, Keith Siau, Waldemar Uhl, Wolfgang Schmidt, Christian Torres Reyes. Ingestible sensor capsule with extended battery capacity allows early diagnosis of GI malignancy in comorbid patients with occult bleeding and anemia. Endosc Int Open 2025; 13: a24749966.
DOI: 10.1055/a-2474-9966
 

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