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DOI: 10.1055/a-2499-2469
Direct Access to 5,6-Dihydropyrido[2′,1′:2,3]pyrido-Fused Imidazo [4,5-c]quinolines via Consecutive C–N and C–C Bond Formation in Deep Eutectic Solvent under Microwave Irradiation
The authors thank the DST-Govt. of India for the funding provided through DST-SERB-YSS/2015/000450 and VIT for providing the VIT SEED Grant-RGEMS Fund (SG20220031) to carry out this research work.
Abstract
Deep eutectic solvents (DESs) are a novel class of ionic liquids that have recently gained considerable attention as a sustainable, nontoxic substitute for traditional organic solvents; recent years have seen an increasing demand for DES systems to synthesize various heterocyclic moieties. Polyheterocycle-containing scaffolds are important as potential therapeutic agents. Herein, we reported a tandem methodology for the synthesis of rarely explored 5,6-dihydropyrido[2′,1′:2,3]imidazo[4,5-c]quinolines and pyrido[2′,1′:2,3]imidazo[4,5-c]quinolines in a choline chloride based DES medium under microwave irradiation. This sustainable approach offers a clean, straightforward synthetic strategy under mild reaction conditions for the synthesis of a wide range these compounds in excellent yields.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/a-2499-2469.
- Supporting Information
Publikationsverlauf
Eingereicht: 25. September 2024
Angenommen nach Revision: 09. Dezember 2024
Accepted Manuscript online:
09. Dezember 2024
Artikel online veröffentlicht:
20. Januar 2025
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