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Synlett
DOI: 10.1055/a-2500-7798
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Enzymatic Peroxidation in the Chemoenzymatic Synthesis of 13-Oxoverruculogen

Chi Pan Ting 
1   Chemistry, Brandeis University, Waltham, United States (Ringgold ID: RIN8244)
,
Brandon Singh 
2   chemistry, Brandeis University, Waltham, United States (Ringgold ID: RIN8244)
› InstitutsangabenGefördert durch: NIH Shared Instrumentation Program 1S10OD034395
Gefördert durch: National Institute of General Medical Sciences T32 GM135126
Gefördert durch: National Science Foundation CHE-2338495
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Verruculogens are fumitremorgin alkaloids that contain an eight-membered endoperoxide ring. Due to their unusual structure and bioactivity, there has been much interest in these natural products since their discovery over forty years ago. Similarly, interest in their biosynthesis resulted in the discovery of verruculogen synthase (FtmOx1) that catalyzes endoperoxide formation in these natural products. Herein, we describe our work in this area through the chemoenzymatic synthesis of 13-oxoverruculogen by endoperoxidation of a substrate analog using FtmOx1.



Publikationsverlauf

Eingereicht: 21. Oktober 2024

Angenommen nach Revision: 11. Dezember 2024

Accepted Manuscript online:
11. Dezember 2024

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