Photodriven Site-Selective Deuteration of Pyridyl Ketones with Deuterium Oxide

Abstract

In this work, a photodriven phosphine/D₂O-mediated method for the reductive deuteration of pyridyl ketones was developed. By regulating the reaction conditions, site-selective deuteration of pyridyl diketones was achieved with high deuterium-incorporation rates.

Key word

deuteration - photocatalysis - site selectivity - deuterium oxide - pyridyl ketones

Publication History

Received: 06 December 2024

Accepted after revision: 30 December 2024

Accepted Manuscript online:
30 December 2024

Article published online:
05 February 2025

• References and Notes

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