Photodriven Site-Selective Deuteration of Pyridyl Ketones with Deuterium Oxide

Abstract

In this work, a photodriven phosphine/D₂O-mediated method for the reductive deuteration of pyridyl ketones was developed. By regulating the reaction conditions, site-selective deuteration of pyridyl diketones was achieved with high deuterium-incorporation rates.

Key word

deuteration - photocatalysis - site selectivity - deuterium oxide - pyridyl ketones

Publikationsverlauf

Eingereicht: 06. Dezember 2024

Angenommen nach Revision: 30. Dezember 2024

Accepted Manuscript online:
30. Dezember 2024

Artikel online veröffentlicht:
05. Februar 2025

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