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DOI: 10.1055/a-2526-0356
Steroidal Adducts and Andrastin-Type Meroterpenoids from the Co-culture of Two Isodon Species-Associated Endophytic Fungi
This work was financially supported by the National Science Fund for Distinguished Young Scholars (82325047), National Natural Science Foundation of China (NSFC)-Joint Foundation of Yunnan Province (U2002221), Youth Innovation Promotion Association of the Chinese Academy of Sciences (2023409), Major Projects for Fundamental Research of Yunnan Province (202201BC070002), the Chinese Academy of Sciences “Light of West China” Program and the Chinese Academy of Sciences Interdisciplinary Innovation Team (xbzg-zdsys-202303), and Yunnan Province Science and Technology Department (202305AH340005).
Abstract
Ergopolyketides A–D, presumably biosynthesized through Diels–Alder additions between ergosterol and polyketides, along with two new andrastin-type meroterpenoids, isopenicins D and E, were isolated from the co-culture of endophytic fungi Penicillium sp. sh18 and Pestalotiopsis sp. HS30, both, inhabiting Isodon species. The structures of these compounds were elucidated using spectroscopic analysis, single-crystal X-ray diffraction, and quantum chemical calculations. Isopenicin D and a known compound, peniandrastin D, exhibited moderate cytotoxic activities against human cancer cell lines HL-60, A549, and SMMC-7721, with IC50 values ranging from 13.37 to 29.17 μM.
Key words
Isodon - endophytic fungi - steroidal adducts - andrastin-type meroterpenoids - cytotoxic activity - quantum chemical calculations - configuration determinationSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/a-2526-0356.
- Supporting Information
- CIF File
Publication History
Received: 04 November 2024
Accepted after revision: 27 January 2025
Accepted Manuscript online:
27 January 2025
Article published online:
14 March 2025
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