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Synfacts 2008(12): 1321-1321  
DOI: 10.1055/s-0028-1083585
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Practical Heck-Mizoroki Coupling Mediated by a Novel Palladacycle

Contributor(s): Paul Knochel, Andrei Gavryushin
E. A. B. Kantchev, G.-R. Peh, C. Zhang, J. Y. Ying*
Institute of Bioengineering and Nanotechnology, Singapore
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Publication History

Publication Date:
20 November 2008 (online)

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Significance

The authors developed a novel, highly active Pd catalyst for the Heck-Mizoroki reaction. It is stable to air and moisture and is easy to prepare in a large scale. This catalyst is highly efficient for the Heck reaction with challenging substrates, where previously known catalysts usually fail. Important functional groups like amines or phenols do not interfere the process.