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Synfacts 2009(1): 0008-0008  
DOI: 10.1055/s-0028-1087230
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of Crisamicin A

Contributor(s): Philip Kocienski, Zofia Komsta
Z. Li, Y. Gao, Y. Tang, M. Dai, G. Wang, Z. Wang*, Z. Yang*
Peking University, Beijing, P. R. of China
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Publikationsdatum:
18. Dezember 2008 (online)

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Significance

Crisamicin A, isolated from the bacterium Micromonospora purpureochromogenes, showed some activity against B16 mouse murine melanoma cells, herpes simplex and vesicular stomatis viruses. The focal steps of the synthesis are: (1) Pd-catalyzed carbonylative lactonization (A + CO → B) and (2) Pd-catalyzed ­homocoupling of H to give the biaryl J.