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Synfacts 2009(1): 0012-0012
DOI: 10.1055/s-0028-1087238
DOI: 10.1055/s-0028-1087238
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag
Stuttgart ˙ New York
Synthesis of Tamiphosphor
J.-J. Shie, J.-M. Fang*, C.-H. Wong
National Taiwan University and Academica Sinica, Taipei, Taiwan
Further Information
Publication History
Publication Date:
18 December 2008 (online)
Significance
Tamiphosphor is a neuraminidase inhibitor that is more effective against the H1N1 human influenza virus than tamiflu and equally effective against the recombinant H5N1 (N1BRG14) virus. The synthesis of tamiphosphor depicted uses a Pd-catalyzed phosphonylation of bromoalkene G to install the phosphonic acid moiety.