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Synfacts 2009(1): 0012-0012  
DOI: 10.1055/s-0028-1087238
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of Tamiphosphor

Contributor(s): Philip Kocienski
J.-J. Shie, J.-M. Fang*, C.-H. Wong
National Taiwan University and Academica Sinica, Taipei, Taiwan
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Publikationsverlauf

Publikationsdatum:
18. Dezember 2008 (online)

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Significance

Tamiphosphor is a neuraminidase inhibitor that is more effective against the H1N1 human influenza virus than tamiflu and equally effective against the recombinant H5N1 (N1BRG14) virus. The synthesis of tamiphosphor depicted uses a Pd-catalyzed phosphonylation of bromo­alkene G to install the phosphonic acid moiety.