RSS-Feed abonnieren
Bitte kopieren Sie die angezeigte URL und fügen sie dann in Ihren RSS-Reader ein.
https://www.thieme-connect.de/rss/thieme/de/10.1055-s-00000131.xml
Synfacts 2008(12): 1252-1252
DOI: 10.1055/s-0028-1087289
DOI: 10.1055/s-0028-1087289
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag
Stuttgart ˙ New YorkFormal Synthesis of (-)-Haouamine
A. Fürstner*, J. Ackerstaff
Max-Planck-Institut für Kohlenforschung, Mülheim/Ruhr, Germany
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
20. November 2008 (online)

Significance
Haouamine A is isolated from the marine ascidian Aplidium haouarianum and exhibits selective cytotoxicity against the human colon carcinoma cell line HT-29 (IC50 = 0.1mg/mL). This formal synthesis primarily uses catalytic reactions to access intermediate L, previously reported by P. S. Baran and co-workers Angew. Chem. Int. Ed. 2008, 47, 205 (10 steps, 5.6%).