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Synfacts 2009(1): 0046-0046
DOI: 10.1055/s-0028-1087408
DOI: 10.1055/s-0028-1087408
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag
Stuttgart ˙ New York
Enantioselective Hydroarylation-Cycloisomerization of 1,6-Enynes
P. Y. Toullec, C.-M. Chao, Q. Chen, S. Gladiali, J.-P. Genêt, V. Michelet*
École Nationale Supérieure de Chimie de Paris, France; Università di Sassari, Italy
Further Information
Publication History
Publication Date:
18 December 2008 (online)
Significance
This catalytic reaction is a good example of the atom-economy principle: two C-C bonds are created with good enantio- and excellent diastereoselectivity. Several protocols have been reported for the cycloisomerization of enynes, most employing Au(I) or Pt(II) catalysts, but highly enantioselective processes have remained elusive. The authors opted to tackle this challenge with a Pt(II) catalyst for its ability to accept four ligands, whereas Au(I) is limited to two.