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Synfacts 2009(1): 0071-0071
DOI: 10.1055/s-0028-1087432
DOI: 10.1055/s-0028-1087432
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag
Stuttgart ˙ New York
Copper-Catalyzed Enantioselective Reduction of Ketones
C.-T. Lee, B. H. Lipshutz*
University of California, Santa Barbara, USA
Further Information
Publication History
Publication Date:
18 December 2008 (online)
![](https://www.thieme-connect.de/media/synfacts/200901/lookinside/thumbnails/10.1055-s-0028-1087432-1.jpg)
Significance
Several routes to optically active diarylmethanols exist to date, including enzymatic and 1,2-addition of organoaryl compounds to aldehydes. There are only a few studies related to the copper hydride catalyzed reduction of diarylketones. This report provides enantiomerically enriched diarylmethanols in good yields and enantioselectivity.