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Synfacts 2009(1): 0071-0071  
DOI: 10.1055/s-0028-1087432
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Copper-Catalyzed Enantioselective Reduction of Ketones

Contributor(s): Hisashi Yamamoto, Joshua P. Abell
C.-T. Lee, B. H. Lipshutz*
University of California, Santa Barbara, USA
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Publication History

Publication Date:
18 December 2008 (online)

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Significance

Several routes to optically active ­diarylmethanols exist to date, including enzymatic and 1,2-addition of organoaryl compounds to aldehydes. There are only a few studies related to the copper hydride catalyzed reduction of di­arylketones. This report provides enantiomerically enriched diarylmethanols in good yields and enantioselectivity.