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Synfacts 2009(1): 0051-0051  
DOI: 10.1055/s-0028-1087434
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Chemo-Enzymatic Resolution of
β-Haloalcohols

Contributor(s): Hisashi Yamamoto, Marina Naodovic
R. M. Haak, F. Berthiol, T. Jergphagnon, A. J. A. Gayet, C. Tarabiono, C. P. Postema, V. Ritleng, M. Pfeffer, D. B. Janssen*, A. J. Minnaard, B. L. Feringa*, J. G. de Vries*
University of Groningen, DSM Pharmaceutical Products, Geleen, The Netherlands; Université Louis Pasteur, Strasbourg, France
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Publication History

Publication Date:
18 December 2008 (online)

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Significance

Chemo-enzymatic dynamic kinetic resolution (DKR) of racemic substrates is a concept first introduced in the 1990s. Since then, several highly efficient protocols have been published. Still, the resolution of β-haloalcohols has not received wide attention. This report represents the first chemo-enzymatic resolution of β-halo­alcohols which provides access to enantio­enriched epoxides.