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Synfacts 2009(1): 0077-0077
DOI: 10.1055/s-0028-1087445
DOI: 10.1055/s-0028-1087445
Metal-Mediated Synthesis
© Georg Thieme Verlag
Stuttgart ˙ New York
Microwave-Enhanced Zincation of Arenes and Heteroarenes
S. Wunderlich, P. Knochel*
Ludwig-Maximilians-Universität, München, Germany
Further Information
Publication History
Publication Date:
18 December 2008 (online)
![](https://www.thieme-connect.de/media/synfacts/200901/lookinside/thumbnails/10.1055-s-0028-1087445-1.jpg)
Significance
Direct metalation of polysubstituted arenes is a highly attractive method of their further functionalization, allowing straightforward routes toward complex industrially important molecules. The compatibility with functional groups makes the use of zincation preferable over the conventional lithiation or magnesiation reactions, offering an outstanding range of functional group compatibility. This method allows simple functionalization of relatively inactive substrates, which were formerly problematic for direct metalation.