Microwave-Enhanced Zincation of Arenes and Heteroarenes

Significance

Direct metalation of polysubstituted arenes is a highly attractive method of their further functionalization, allowing straightforward routes toward complex industrially important molecules. The compatibility with functional groups makes the use of zincation preferable over the conventional lithiation or magnesiation reactions, offering an outstanding range of functional group compatibility. This method allows simple functionalization of relatively inactive substrates, which were formerly problematic for direct metalation.