Synfacts 2009(1): 0080-0080  
DOI: 10.1055/s-0028-1087451
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Mild Enantiopure Synthesis of α-Amino Ketones from Thiol Esters

Contributor(s): Paul Knochel, Andreas J. Wagner
H. Li, H. Yang, L. S. Liebeskind*
Emory University, Atlanta, USA
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Publikationsverlauf

Publikationsdatum:
18. Dezember 2008 (online)

Significance

Herein, the authors describe a novel efficient synthesis of enantiopure N-protected α-amino ketones starting from chiral thiol esters. This Pd-catalyzed, copper diphenylphosphinate mediated reaction proceeds under mild and pH-neutral conditions and gives the amino ketones in high yields and very high enantiopurity.