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Synfacts 2009(1): 0084-0084
DOI: 10.1055/s-0028-1087457
DOI: 10.1055/s-0028-1087457
Metal-Mediated Synthesis
© Georg Thieme Verlag
Stuttgart ˙ New York
Mild Pd-Catalyzed Amination of Aryl and Heteroaryl Tosylates
T. Ogata, J. F. Hartwig*
University of Illinois, Urbana, USA
Further Information
Publication History
Publication Date:
18 December 2008 (online)
![](https://www.thieme-connect.de/media/synfacts/200901/lookinside/thumbnails/10.1055-s-0028-1087457-1.jpg)
Significance
This important article demonstrates that (hetero)aryl tosylates can be efficiently converted in Pd-catalyzed amination reactions. Tosylates can be easily accessed from the corresponding phenols and are unlike triflates less expensive to prepare and give stable, crystalline solids. The reaction tolerates sensitive functionalities and proceeds even with electron-rich and sterically hindered substrates.