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Synfacts 2009(1): 0029-0029
DOI: 10.1055/s-0028-1087470
DOI: 10.1055/s-0028-1087470
Synthesis of Heterocycles
© Georg Thieme Verlag
Stuttgart ˙ New York
Magnesium Nitride as a Source of Ammonia for the Paal-Knorr Synthesis of Pyrroles
G. E. Veitch, K. L. Bridgwood, K. Rands-Trevor, S. V. Ley*
University of Cambridge, UK
Further Information
Publication History
Publication Date:
18 December 2008 (online)
Significance
Reported is an improvement of the well-known Paal-Knorr protocol for the synthesis of pyrroles from 1,4-dicarbonyl compounds using magnesium nitride as a source of ammonia. The reaction is performed under conventional and microwave heating resulting in the products in good to excellent preparative yields. The key point of the procedure is an alcoholysis of Mg3N2 generating ammonia in situ gradually.