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Synfacts 2009(2): 0171-0171  
DOI: 10.1055/s-0028-1087638
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Selective Carbene Insertion into Primary C-H Bonds

Contributor(s): Mark Lautens, Jane Panteleev
H.-Y. Thu, G. S.-M. Tong, J.-S. Huang, S. L.-F. Chan, Q.-H. Deng, C.-M. Che*
The University of Hong Kong and Shanghai Institute of Organic Chemistry, P. R. of China
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Publikationsdatum:
22. Januar 2009 (online)

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Significance

The authors report their work on C-H bond functionalization using rhodium-porphyrinoid catalysts. Carbene insertion into primary hydrocarbon C-H bonds is reported to occur with moderate to high regioselectivity. Additionally, an enantioselective variant of the reaction is reported, giving products in moderate yield and enantio­selectivity.