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Synfacts 2009(3): 0245-0245
DOI: 10.1055/s-0028-1087697
DOI: 10.1055/s-0028-1087697
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag
Stuttgart ˙ New York
Formal Synthesis of Platencin
K. C. Nicolaou*, Q.-Y. Toh, D. Y.-K. Chen*
Institute of Chemical and Engineering Sciences, Singapore
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
19. Februar 2009 (online)
Significance
Platencin targets a broad range of bacteria including drug-resistant strains such as MRSA (methicillin-resistant Staphylococcus aureus), vancomycin-resistant enterococci and Streptococcus pneumoniae. Platencin possesses dual activity and inhibits the fatty acids synthesis pathway in bacteria by binding to both the enzymes FabH and FabF.